Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall

By Philip W. Harvey, David J. Everett, Christopher J. Springall

Despite being considered as the commonest toxicological aim within the endocrine method, the adrenal gland has frequently been missed in regulatory trying out. Adrenal Toxicology addresses the elevated curiosity in adrenocortical toxicology and the necessity for a source that makes ideas on hand to envision adrenal endocrine disruption.

Examining present concepts and the newest developments, Adrenal Toxicology experiences the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. this article presents info at the variety of substances and chemical compounds that impact adrenocortical functionality and indicates standardized ways for in vivo and in vitro evaluation. This quantity additionally provides fresh advancements within the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.

Adrenal Toxicology :

  • reflects the most important advancements revamped the prior decade
  • focuses at the newest examine concepts, together with their makes use of and limitations
  • provides an built-in approach for adrenal toxicology evaluation
  • identifies wisdom and information gaps, supplying impetus for regulatory consideration

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Toxicol Appl Pharmacol 2005; 209:95–104. Li LA, Lin TC. Interacting influence of potassium and polychlorinated biphenyl on cortisol and aldosterone biosynthesis. Toxicol Appl Pharmacol 2007; 220:252–261. Li LA, Wang PW. PCB126 induces differential changes in androgen, cortisol and aldosterone biosynthesis in human adrenocortical H295R cells. Toxicol Sci 2005; 85:530–540. 30 Harvey et al. Li LA, Wang PW, Chang LW. Polychlorinated biphenyl 126 stimulates basal and inducible aldosterone biosynthesis of human adrenocortical H295R cells.

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